Enhancing Immune Cell Trafficking to Tumours to Improve the Therapy of Breast Cancer

CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

IG House, EB Derrick, K Sek, AXY Chen, J Li, J Lai, KL Todd, I Munoz, J Michie, CW Chan, YK Huang, JD Chan, EV Petley, J Tong, DM Nguyen, S Engel, P Savas, SJ Hogg, SJ Vervoort, CJ Kearney

2023-08-29

CXCL9 expression is a strong predictor of response to immune checkpoint blockade therapy. Accordingly, we sought to develop therap..